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Mast cells and tumor angiogenesis
Author(s) -
Kessler David A.,
Langer Robert S.,
Pless Naomi A.,
Folkman Judah
Publication year - 1976
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910180520
Subject(s) - angiogenesis , chorioallantoic membrane , mast cell , embryo , neovascularization , implant , biology , medicine , pathology , endocrinology , immunology , microbiology and biotechnology , cancer research , surgery
Tumor angiogenesis factor (TAF) elicits a strong vasoproliferative response when implanted upon the chorioallantoic membrane (CAM) of the chick embryo. This response is first observed stereomicroscopically 2–3 days after implantation. A 40‐fold increase in mast cell density is observed within the vicinity of this implant by 24 h. Mast cells that have been isolated from retired breeder Sprague‐Dawley rats fail to evoke a vascular reaction when implanted on the CAM. An intermediate role for the mast cell in tumor angiogenesis is suggested.