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Demonstration of a phase (stage)‐specific embryonic brain antigen in human meningioma
Author(s) -
Kehayov I.,
Botev B.,
Vulchanov V.,
Kyurkchiev S.
Publication year - 1976
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910180507
Subject(s) - antigen , human brain , antiserum , embryonic stem cell , embryo , biology , immunodiffusion , immunoelectrophoresis , pathology , meningioma , immunology , medicine , microbiology and biotechnology , neuroscience , biochemistry , gene
The water‐soluble antigens of human embryonic brain were studied using a rabbit antiserum to human 8‐ to 10‐week embryonic brain (non‐absorbed and absorbed with extracts of human embryonic and adult organs). A phase (stage)‐specific brain antigen (s) characteristic for the human 8‐ to 10‐week‐old embryo was detected by double immunodiffusion and immunoelectrophoresis in agarose gel. The testing of this anti‐embryonic brain serum against saline extracts of human brain tumours (meningiomas, glioblastomas, astrocytomas, neurinomas and brain metastasis of carcinoma) revealed the presence of an “embryonic” antigen in the human meningioma only. Immunochemically this meningioma‐associated antigen is identical to a phase (stage)‐specific antigen of the 8‐ to 10‐week embryo.