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Serum alpha‐fetoprotein as a marker for the effect of post‐operative radiation therapy and/or chemotherapy in eight cases of ovarian endodermal sinus tumour
Author(s) -
Sell A.,
Søgaard H.,
NørgaardPedersen B.
Publication year - 1976
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910180505
Subject(s) - endodermal sinus tumor , alpha fetoprotein , medicine , chemotherapy , dysgerminoma , yolk sac , immature teratoma , radiation therapy , sinus (botany) , tumor marker , teratoma , pathology , choriocarcinoma , gastroenterology , ovary , cancer , germ cell tumors , biology , embryo , botany , hepatocellular carcinoma , genus , microbiology and biotechnology
The clinical pathological findings of eight cases of ovarian endodermal sinus tumour (yolk sac tumour) are presented. Histological examination in all eight cases showed a typical endodermal sinus tumour pattern, and in six of the patients other tumour elements such as dysgerminoma, choriocarcinoma, malignant teratoma, endometriosis, and a dermoid cyst were also found. Six patients had increased serum alpha‐fetoprotein concentration in the postoperative period, and two patients had a normal concentration 27 and 35 days after operation, respectively. In all cases except one, a close correlation between serum alpha‐fetoprotein and progression or regression of tumour was found. Serum alpha‐fetoprotein was thus found to be a reliable parameter in post‐operative radiation and/or chemotherapy (VAMBLE). In one patient who died 10 months after operation with widespread endodermal sinus tumour growth, only a small terminal increase in serum alpha‐fetoprotein concentration was found. Four of the eight women are still alive with normal alpha‐fetoprotein concentration, and without clinical evidence of tumour disease.