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Human thymus/leukemia‐associated antigen in normal and leukemic cells
Author(s) -
Chechik B. E.,
Pyke K. W.,
Gelfand E. W.
Publication year - 1976
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910180502
Subject(s) - lymphoblast , leukemia , antigen , acute myeloblastic leukemia , immunology , tonsil , bone marrow , precursor cell , biology , microbiology and biotechnology , spleen , antiserum , cell , cell culture , genetics
A saline extractable human thymus/leukemia‐associated antigen (HThy‐L) has been detected in immunodiffusion using rabbit antisera raised to human thymus extracts. HThy‐L was demonstrated in extracts of normal thymocytes, lymphocytes from E‐rosetting T‐cell lines and from the blast cells of patients with E‐rosetting acute lymphoblastic leukemia. Extracts of leukemic cells from patients with acute myeloblastic leukemia and E‐rosette‐negative acute lymphoblastic leukemia contained significantly lower quantities of HThy‐L. Only trace amounts of the antigen were detected in normal spleen, tonsil, peripheral blood, bone marrow and PHA‐induced lymphoblasts. HThy‐L appears to be an antigen associated with the intrathymic differentiation of human T cells and a marker of leukemic cells in certain forms of acute leukemia.