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Emergence of a subpopulation of lymphocytes bearing θ antigen and complement receptor during tumor growth
Author(s) -
Epstein Robert S.,
Lopez Diana M.,
OrtizMuniz Gabriel,
Sigel M. Michael
Publication year - 1976
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910180410
Subject(s) - spleen , immunofluorescence , antigen , biology , population , antibody , complement receptor , indirect immunofluorescence , receptor , immunology , pathology , microbiology and biotechnology , complement system , medicine , biochemistry , environmental health
Abstract Spleens from BALB/c mice transplanted with mammary tumors display a significant increase in the percentage of lymphocytes bearing complement receptors (CRL) while the percentage of cells bearing surface immunoglobulins (SIg) remains unchanged in comparison with that in spleens from normal animals. Upon separation on nylon columns, the increase in CRL in the spleens from tumor‐bearing mice was limited to the non‐adherent cell population. Simultaneous marker analysis disclosed that these CRL lacked detectable SIg. Indirect immunofluorescence indicated that these cells possessed theta antigen. Absence of SIg and the presence of theta antigen coupled with the restricted occurrence of these cells in the nylon‐non‐adherent population which responded to PHA and Con A but not to LPS indicate that these cells may constitute a subset of T cells. The paucity of this subpopulation of spleen lymphocytes in normal spleen suggests that their emergence is related to tumor growth.