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Specific anti‐fibroblast cytotoxicity of antibodies to fibroblast surface antigen
Author(s) -
Ruoslahti Erkki,
Sjögren Hans O.
Publication year - 1976
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910180317
Subject(s) - cytotoxic t cell , cytotoxicity , fibroblast , hela , antiserum , antigen , cell culture , antibody , microbiology and biotechnology , biology , cancer research , chemistry , immunology , in vitro , biochemistry , genetics
Abstract An antiserum to SF antigen was shown to be selectively cytotoxic to two human fibroblast lines, while two tumor cell lines (one melanoma and one Hela cell line) were resistant. The selective cytotoxicity was also demonstrable in mixtures of fibroblasts and tumor cells. The cytotoxic effect was abrogated by admixture of human serum containing SFA.