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Oncogenicity of k‐region epoxides of benzo( a )pyrene and 7,12‐dimethylbenz( a )anthracene
Author(s) -
Flesher James W.,
Harvey Ronald G.,
Sydnor Katherine L.
Publication year - 1976
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910180313
Subject(s) - dmba , 7,12 dimethylbenz[a]anthracene , pyrene , benzo(a)pyrene , anthracene , carcinogen , epoxide , mole , chemistry , sarcoma , toxicology , medicine , biochemistry , biology , organic chemistry , pathology , carcinogenesis , gene , catalysis
Female Sprague‐Dawley rats were given a subcutaneous injection of the parent hydrocarbon or its K‐region epoxide in 0.1 ml sesame oil on alternate days to a total of 30 doses and observed for sarcoma at the site of injection for 275 days. The parent compounds, benzo(a) pyrene (0.2 μmole/dose) and 7,12‐dimethylbenz (a) anthracene (0.2 μmole/dose), induced sarcoma in 100% of the animals with an average latent period of 101 and 95 days, respectively, whereas five of 12 rats (42%) injected with the K‐region epoxide of B (a) P (1.0 μmole/dose), developed sarcoma in 151±22 days, and the K‐region epoxide of DMBA (0.4 μmole/dose) failed to elicit tumors. Under these experimental conditions, these K‐region epoxides are, at best, only weak carcinogens.