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Murine neuroblastoma clones with varying degrees of C‐type virus expression
Author(s) -
Wivel Nelson A.,
Yang Stringner S.
Publication year - 1976
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910180214
Subject(s) - clone (java method) , virus , virology , biology , karyotype , microbiology and biotechnology , cell culture , neuroblastoma , chromosome , gene , genetics
Three tissue culture clones of neuroblastoma cells derived from the C‐1300 tumor in strain A/J mice were found to contain type‐C virus‐specific gs antigen. None of the clones spontaneously released mousetropic type‐C viruses although one clone, N‐4, spontaneously released a xenotropic virus. Two clones, NB‐2A and N‐4, could be induced by treatment with 5‐iododeoxyuridine and dexamethasone phosphate to produce B‐tropic type‐C virus, but clone N‐18 failed to release either ecotropic or xenotropic virus under several different induction conditions. Karyotype analysis did not reveal specific chromosome deletions in clone N‐18.