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Genetic role of rat macrophage cytotoxicity against tumor
Author(s) -
Miller Glenn A.,
Feldman Joseph D.
Publication year - 1976
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910180206
Subject(s) - cytotoxic t cell , biology , cytotoxicity , histocompatibility , in vivo , antigen , macrophage , major histocompatibility complex , immunology , strain (injury) , sarcoma , virology , cancer research , in vitro , genetics , pathology , human leukocyte antigen , medicine , anatomy
Macrophages from the Lewis (Le) rat strain are significantly more cytotoxic to a Moloney sarcoma tumor, both in vivo and in vivo , than are macrophages from the Brown Norway (BN) strain. Activity of macrophages from (Le × BN) F 1 rats that are histocompatible with the Moloney sarcoma tumor is directed toward tumor and/or virus‐associated antigens and is expressed as a dominant genetic trait. Experiments with backcross rats suggest that the genetic factors are unrelated to the major histocompatibility locus (AgB) of the rats. BN macrophages, although not active against tumor and/or viral antigens, can become cytotoxic to cells displaying Le alloantigens.