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Transplacental induction of lymphomas in Swiss mice by carbendazim and sodium nitrite
Author(s) -
Börzsönyi Mátyás,
Pintér Alán,
Surján András,
Farkas Ilona
Publication year - 1976
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910170609
Subject(s) - carbendazim , benzimidazole , offspring , sodium nitrite , pregnancy , transplacental , medicine , nitrite , in vivo , endocrinology , chemistry , biology , fetus , fungicide , food science , botany , genetics , organic chemistry , placenta , nitrate
Swiss mice at different stages of pregnancy were treated intragastrically with the pesticide Carbendazim (MBC., BCM, methyl‐2‐benzimidazole carbamate) together with sodium nitrite. Lymphomas developed in 33.3% of young mice whose mothers were treated in the first week of pregnancy, in 53.3 % of those whose mothers were treated during the second week, and in 38.8% of those born of mothers treated during the third week. Treatment during the whole period of pregnancy yielded on an average 70.0% malignancy in offspring. However, administration of Carbendazim by itself did not produce lymphomas in the first generation. In lymphomas induced by in vivo‐formed N‐nitroso compounds, A‐ and C‐type oncornavirus particles were observed with the electron microscope.