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AKR leukemia‐specific surface antigens acquired by malignant transformation: Their common and individual specificities
Author(s) -
Okazaki Etsuo,
Aoki Tadao,
De Kozlowski Steven J.
Publication year - 1976
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910170513
Subject(s) - antigen , antiserum , leukemia , immunofluorescence , virus , virology , biology , antibody , pan t antigens , microbiology and biotechnology , murine leukemia virus , immunology , monoclonal antibody
Antisera against five newly established AKR spontaneous leukemias (KSL) prepared by immunization of KSL cells in (C57Bl/6xC 3 Hf/He)F 1 mice were preabsorbed with non‐leukemic AKR lymphoid cells to remove antibodies against virus‐associated surface antigens and alloantigens. In absorption tests the antisera showed no cross‐reaction by immunofluorescence microscopy with thymocyte, fetal, male‐specific H‐Y, E and X.1 antigens; with known Gross murine leukemia virus‐associated antigens; or with cell surface antigens on Friend, Moloney and Rauscher virus‐induced tumors. It was thus shown that the antigens detected were leukemia‐specific, were acquired by malignant transformation, and consisted of two types: (1) a common antigen in all the KSL, and (2) individual antigens found in four of the KSL which showed distinct patterns of partial cross‐reactivity with the other KSL.