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Capillary tube leukocyte adherence inhibition: An assay for cell‐mediated immunity in cancer patients
Author(s) -
Urist Marshall M.,
Boddie Arthur W.,
Holmes E. Carmack,
Morton Donald L.
Publication year - 1976
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910170309
Subject(s) - medicine , antigen , carcinoma , immunity , lung cancer , immunology , lung , oncology , pathology , immune system
The leukocyte adherence inhibition (LAI) assay has been modified and automated in order to facilitate its clinical application. This new assay‐the capillary tube LAI test‐correlated with delayed cutaneous hypersensitivity using streptokinase‐streptodornase antigen in 83% of the cases. When tested with a 3 m KCI lung carcinoma antigen, lung carcinoma patients' leukocytes were more frequently inhibited (55%) than those of controls (normals 6%, other tumors 20%).