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Lymphoblastic lymphoma of convoluted or acid phosphatase type‐A tumor of T precursor cells
Author(s) -
Stein H.,
Petersen N.,
Lennert K.,
Gaedicke G.,
Landbeck G.
Publication year - 1976
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910170303
Subject(s) - receptor , lymphoma , antibody , lymphoblastic lymphoma , surface immunoglobulin , acid phosphatase , biology , neuraminidase , pathology , microbiology and biotechnology , immunology , virus , b cell , enzyme , medicine , biochemistry , t cell , immune system
Five lymphatic neoplasms with strong focal acid phosphatase reactivity were selected from a group of acute lymphocytic leukemias and lymphoblastic lymphomas. All five cases showed an anterior mediastinal mass and exhibited identical morphology. This type of lymphoma has been described by Lukes under the term “malignant lymphoma of convoluted lymphocytes”. Analysis of surface membrane receptors revealed that the tumor cells lacked surface immunoglobulin and receptors for Fc‐fragment, but possessed receptors for complement (C3), untreated SRBC (E s ) and SRBC treated with neuraminidase (E s N ). By appliying a mixed rosette assay using nucleated chicken erythrocytes coated with antibodies and C3, and denucleated E s N , it was found that a considerable number of tumor cells in all five cases formed mixed rosettes, i.e. that they bore the C3 receptor characteristic of B cells and simultaneously the E receptor characteristic of T cells. Thus the tumor cells resembled immature thymocytes of 10‐15 weeks' gestation, which also show focal acid phosphatase reactivity and simultaneous expression of C3 and E receptors.