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Host responses within solid tumors: Non‐thymus‐derived specific cytotoxic cells within a murine mammary adenocarcinoma
Author(s) -
Haskill J. Stephen,
Yamamura Y.,
Radov L.
Publication year - 1975
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910160512
Subject(s) - cytotoxic t cell , cytotoxicity , biology , receptor , adenocarcinoma , population , cell culture , mammary gland , microbiology and biotechnology , immunology , pathology , cancer research , in vitro , cancer , medicine , biochemistry , genetics , environmental health , breast cancer
The nature of host‐derived, specifically cytotoxic cells infiltrating solid murine mammary adenocarcinomas (line T1699) was investigated. Cell suspensions obtained from enzymatically dispersed tumors were separated by sedimentation velocity. The host cell fraction was heterogeneous and contained T‐lymphocytes, non‐phagocytic cells bearing Fc receptors, eosinophils and monocytes. Host cells equivalent in size to small lymphocytes and bearing Fc receptors were found to be the predominant cell type responsible for colony inhibition. These colony‐inhibiting cells were insensitive to lysis with either anti‐θ or anti‐IgG serum and complement; and they were specific both in their induction and in their mediation of cytotoxicity. Host cells made up the predominant population in spontaneously regressive tumors but only a minor component in progressive tumors, and they were totally absent from progressive tumors in X‐irradiated animals.