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A study of the oncogenicity of adenovirus type 2 transformed rat embbyo cells
Author(s) -
Harwood Lesley M. J.,
Gallimore P. H.
Publication year - 1975
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910160317
Subject(s) - antigenicity , cell culture , virology , biology , adenoviridae , virus , mastadenovirus , microbiology and biotechnology , genetics , antibody , gene , recombinant dna
Rat embryo cells were transformed by adenovirus type 2 at different multiplicities of infection. The oncogenic potential of the resulting transformed lines varied considerably but a relationship was found to exist between transforming virus dose and oncogenicity of the resulting transformed lines. Possible reasons for the considerable variation in oncogenicity of the transformed lines are discussed, giving particular consideration to cellular antigenicity and recent molecular biology studies of adenovirus type 2 transformed cell lines.