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Genetic control of oncogenesis by murine sarcoma virus moloney pseudotype. I. Genetics of resistance in AKR mice
Author(s) -
Colombatti A.,
Collavo D.,
Biasi G.,
ChiecoBianchi L.
Publication year - 1975
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910160309
Subject(s) - backcrossing , biology , inbred strain , genetics , carcinogenesis , murine leukemia virus , rickettsia , gene , virology , neoplasm , virus , hybrid , strain (injury) , congenic , ratón , immunology , botany , anatomy
Injection of Moloney mouse sarcoma virus (M‐MSV) in adult mice of several inbred strains revealed that all strains except AKR are highly susceptible to M‐MSV tumor development. F1 hybrids between AKR and CBA, DBA/2 or NIH mice are as resistant (93%) as the parental AKR strain, which indicates that resistance is transmitted as a dominant character. First backcross mice to the susceptible parent show a 3:1 ratio of resistant to susceptible mice. This is the expected ratio for two segregating loci which independently confer resistance. The incidence of resistant F2 mice is somewhat lower than expected. Further support for the two‐gene hypothesis was obtained in second backcross mice. None of the major genes affecting MuLV infection (Fv‐2 and H‐2) seems to play any role in this system and no linkage was found with Thy. 1 and albino, dilute, agouti and brown markers.