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A case/control study of the association between primary liver cancer and hepatitis b infection in senegal
Author(s) -
Prince Alfred M.,
Szmuness Wolf,
Michon Jacqueline,
Demaille Jacques,
Diebolt Georgette,
Linhard Jacques,
Quenum Cyprien,
Sankale Marc
Publication year - 1975
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910160304
Subject(s) - medicine , liver cancer , association (psychology) , hepatitis b , primary cancer , cancer , hepatitis , case control study , oncology , psychology , psychotherapist
A case/control study has been carried out to determine by radioimmunoassay and passive hemagglutination techniques the prevalance of hepatitis B surface antigen (HBsAg) and antibody (anti‐HBs) in patients with primary liver cancer (PLC) and age/sex‐matched hospital controls with cancers of other sites (OCC) and similarly matched controls without cancer (NCC). HBsAg was found in 61.2% of 165 cases of PLC as compared to 11.7% of 154 OCC and 11.3% of 328 NCC. The frequency of HBsAg in PLC patients was significantly higher (72.2%) in those with detectable alpha fetoprotein as compared to those without (40.3%). There was no difference in the frequency of HBsAg in PLC patients with and without accompanying cirrhosis. No significant difference in potential hepatitis exposure history was found in the three study groups.