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Distinctive banded marker chromosomes of human tumor cell lines
Author(s) -
NelsonRees Walter A.,
Flandermeyer Robert R.,
Hawthorne Paula K.
Publication year - 1975
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910160109
Subject(s) - karyotype , biology , cell culture , marker chromosome , cytogenetics , chromosome , cell , pathology , genetics , medicine , gene
Nine human tumor cell lines (five breast carcinomas and four sarcomas) have been studied and each revealed groups of distinctive banded marker chromosomes which can serve to identify them and aid in monitoring cell line specificity. This was possible neither by conventional karyology in terms of numbers and morphology of chromosomes nor by glucose‐6‐phosphate‐dehydrogenase mobility which was type B for all cultures. The significance of the clonal nature of the cell lines is discussed.