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Temperature‐sensitive mutants of murine leukemia virus. V. Impaired leukemogenic activity in vivo
Author(s) -
Greenberger Joel S.,
Stephenson John R.,
Aaronson Stuart A.
Publication year - 1975
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910150618
Subject(s) - biology , in vivo , virus , virology , mutant , leukemia , murine leukemia virus , permissive , viral replication , viral transformation , immunology , genetics , gene
The in vivo biologic activities of a clonal isolate of the Rauscher strain of murine leukemia virus and several conditional lethal mutants with impaired replicative functions at the non‐permissive temperature were investigated. The parental virus induced a rapidly developing lymphoid leukemia in a high percentage of NIH Swiss mice inoculated as newborns. Mice inoculated in parallel with temperature‐sensitive mutant viruses showed no evidence of disease. The implications of these findings with regard to the requirements for type‐C virus replication to permit oncogenic transformation of lymphoid cells in vivo are discussed.