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Induction of malignant lymphomas in swiss mice by N‐nitroso compounds formed in vivo
Author(s) -
Börzsönyi Mátyás,
Csik Márta
Publication year - 1975
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910150515
Subject(s) - in vivo , sodium nitrite , benzimidazole , pathology , chemistry , nitroso , medicine , biology , medicinal chemistry , organic chemistry , microbiology and biotechnology
Malignant lymphomas were induced in Swiss mice treated intragastrically with methyl‐2‐benzimidazole carbamate (MBC, BCM, Carbendazim) and given sodium nitrite in their drinking water. The tumours appeared between 82 and 164 days after the beginning of treatment. In 30 mice given MBC and sodium nitrite, 10 lymphosarcomas were found. In the proliferating tumour cells, intracytoplasmic type‐A virus particles were demonstrated by electron microscopy. No tumours were found in animals given MBC only. The findings demonstrate the possibility of in vivo formation of N‐nitroso derivatives from MBC.