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Anti‐tumor antibodies in normal mouse sera
Author(s) -
Martin Sue Ellen,
Martin W. John
Publication year - 1975
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910150415
Subject(s) - antibody , immune system , immunology , biology , cytotoxic t cell , neoplasm , pathology , medicine , in vitro , biochemistry
Evidence for the involvement of the immune system in surveillance against nascent tumors was sought by testing whether normal mouse sera were cytotoxic in the presence of rabbit complement for a variety of lymphoid and non‐lymphoid tumor‐cell lines. Tumor‐reactive antibodies were detected in all mouse sera tested, including sera from congenitally athymic (nude) mice. Considerable variation was noted, however, in the levels of naturally occurring antibodies against specific tumors. Anti‐tumor antibodies were identified as being predominantly IgM. The possible relevance of natural anti‐tumor antibodies to immune surveillance was discussed.