Premium
Tumor‐induced angiogenesis: Lack of inhibition by irradiation
Author(s) -
Auerbach Robert,
Arensman Robert,
Kubai Louis,
Folkman Judah
Publication year - 1975
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910150209
Subject(s) - angiogenesis , cancer research , medicine , biology
The effect of irradiation of tumors on their ability to induce vascular responses (angiogenesis) was studied. Rat Walker carcino‐sarcoma 256, rabbit V2 carcinoma, mouse (C57Bl) melanoma and mouse (129) teratoma (OTT 6050, 100K) were irradiated with up to 5000R, then grafted either to the chicken chorioallantoic membrane or intracorneally into adult rabbits to assess competence to provoke angiogenesis. For all tumors and both assay systems the results were similar: irradiation did not interfere with tumor‐induced vascular responses.