Premium
In vitro immunological studies on east african cancer patients. III. Spontaneous rosette formation by cells from burkitt lymphoma biopsies
Author(s) -
Gross R. L.,
Steel C. M.,
Levin A. G.,
Singh S.,
Brubaker G.
Publication year - 1975
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910150116
Subject(s) - rosette formation , lymphoma , rosette (schizont appearance) , in vitro , cancer , burkitt's lymphoma , medicine , pathology , cancer research , immunology , biology , antibody , genetics
Spontaneous rosette formation was observed in eight out of nine Burkitt lymphoma biopsies. These were examined fresh and/or after culture in vitro for up to 48 h. The percentage of rosettes varied from 3.7% to 38%. There was a tendency for the percentage of rosettes to increase with time in tissue culture. It is suggested that the rosette‐forming cells are T‐lymphocytes infiltrating the tumour and functioning as a host defence mechanism against the proliferating tumour cells.