In vitro  immunological studies on east african cancer patients. III. Spontaneous rosette formation by cells from burkitt lymphoma biopsies | Zendy

Gross R. L. | Zendy; Steel C. M. | Zendy; Levin A. G. | Zendy; Singh S. | Zendy; Brubaker G. | Zendy

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In vitro immunological studies on east african cancer patients. III. Spontaneous rosette formation by cells from burkitt lymphoma biopsies

Author(s) -

Gross R. L.,

Steel C. M.,

Levin A. G.,

Singh S.,

Brubaker G.

Publication year - 1975

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.2910150116

Subject(s) - rosette formation , lymphoma , rosette (schizont appearance) , in vitro , cancer , burkitt's lymphoma , medicine , pathology , cancer research , immunology , biology , antibody , genetics

Spontaneous rosette formation was observed in eight out of nine Burkitt lymphoma biopsies. These were examined fresh and/or after culture in vitro for up to 48 h. The percentage of rosettes varied from 3.7% to 38%. There was a tendency for the percentage of rosettes to increase with time in tissue culture. It is suggested that the rosette‐forming cells are T‐lymphocytes infiltrating the tumour and functioning as a host defence mechanism against the proliferating tumour cells.

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