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Distribution of concanavalin A receptors on normal rat liver cells and zajdela ascites hepatoma cells
Author(s) -
Roth J.
Publication year - 1974
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910140610
Subject(s) - concanavalin a , receptor , internalization , cell surface receptor , ascites , cell , biology , labelling , microbiology and biotechnology , chemistry , biochemistry , medicine , in vitro
The distribution of Concanavalin A receptors in cultures of normal rat liver cells and of Zajdela ascites hepatoma cells of the rat was investigated by the Con A‐po technique (Bernhard and Avrameas, 1971). Con A‐po labelling of the cell surface showed a patchy distribution of Concanavalin A receptors in ascites hepatoma cells, whereas continuous Con A‐po labelling was seen at the surface of normal rat liver cells. The different distribution of Concanavalin A receptors was caused by rapid internalization of Con A‐po labelled material and not by a simple rearrangement of the receptors. The significance of this process is discussed with respect to Concanavalin A receptor mobility and membrane stability after cell transformation.