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Cell interactions in adoptive immune rejection of a syngeneic tumor
Author(s) -
Howell Stephen B.,
Dean Jack H.,
Esber Elaine C.,
Law Lloyd W.
Publication year - 1974
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910140514
Subject(s) - immune system , immunity , effector , adoptive cell transfer , immunology , in vivo , biology , t cell , immune reaction , cancer research , virology , genetics
Studies of adoptive tumor neutralization (the Winn test) in BALB/c mice rendered immune to the Simian Virus 40‐induced tumor mKSA indicate that: a) the reaction is extremely specific; b) there is a very close correlation between immunity detected by the Winn test and the ability of the intact animal to reject tumor; and c) immunity reflected by the 51 chromium lymphocytotoxicity assay (CRA) and microcytotoxicity test (MCI) correlate poorly with in vivo resistance to tumor challenge and the Winn test. Investigation of the contribution of the immune donor lymphocytes to the reaction demonstrated that immune thymus‐dependent lymphocytes (T cells) were essential, but other donor cell populations were not. Proliferation of immune donor cells was not required. Recipient T cells do not participate in the reaction. We propose that donor T cells do not attack the tumor directly, but must interact with recipient cells to generate an effector response. Some of the parameters of the postulated cooperative interaction are discussed.