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Immunochemical identification of beta 1 ‐globulin of the pregnancy zone” in serum of patients with trophoblastic tumors
Author(s) -
Tatarinov Yu. S.,
Mesnyanki. V.,
Nikoulina D. M.,
Novikova L. A.,
Toloknov B. O.,
Falaleeva D. M.
Publication year - 1974
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910140415
Subject(s) - trophoblastic tumor , pregnancy , medicine , uterus , globulin , trophoblastic neoplasm , gestation , placenta , chemotherapy , fetus , obstetrics , gynecology , biology , genetics
Sera from 181 patients, 37 of which suffered from trophoblastic tumors (hydatidiform mole, destructive hydatidiform mole, and chorioepithelioma of the uterus), 100 patients—with other forms of tumors and 44 patients with various gynecological diseases, were studied with the use of an immunological test for the detection of beta 1 ‐globulin of “pregnancy zone”. In the control group there were 106 serum samples of women at different stages of pregnancy and 257 samples of normal adults (165 women and 92 men). Thus, 544 serum samples from patients and from normal adults were studied. The immunochemical test for the beta 1 ‐globulin was positive in patients with trophoblastic tumors before surgical removal or before chemotherapy. After surgery and/or complete course of chemotherapy, the test for beta 1 ‐globulin became, as a rule, negative. This globulin is detected also in normal pregnancy serum. It is supposed that the beta 1 ‐globulin of “pregnancy zone” is synthetized in the placenta and is released in the circulation of women during normal pregnancy; also it is produced by cells of trophoblastic tumors. The diagnostic and prognostic significance of the immunochemical test for the “pregnancy zone” beta 1 ‐globulin in trophoblastic tumors is discussed.