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Early appearance of a lymphoid arming factor and cytotoxic lymph‐node cells after tumor induction
Author(s) -
Pollack Sylvia,
Nelson Karen
Publication year - 1974
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910140412
Subject(s) - cytotoxic t cell , lymph node , sarcoma , in vitro , pathology , lymph , lymphatic system , immunology , tumor cells , cancer research , biology , medicine , biochemistry
An arming factor which collaborates with non‐sensitized lymphoid cells to produce specific killing of tumor cells in vitro appears in the serum within 24‐48 after initiation of a tumor by inoculation of Moloney Sarcoma Virus or a transplant of syngeneic sarcoma cells. Lymph‐node cells taken 1 or 2 days after tumor induction are also specifically cytotoxic in a microcytotoxicity assay. The production of this arming factor and the appearance of cytotoxic lymphoid cells are thus temporally related and are among the early responses to syngeneic sarcomas in BALB/c mice.