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Friend lymphatic leukemia virus‐induced autoimmune hemolytic anemia with glomerulpnephritis in the rat
Author(s) -
Kuzumaki Noboru,
Kodama Takao,
Takeichi Noritoshi,
Kobayashi Hiroshi
Publication year - 1974
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910140408
Subject(s) - autoimmune hemolytic anemia , autoantibody , hemolytic anemia , immunology , coombs test , anemia , leukemia , medicine , lymphatic system , antibody
WKA/Mk rats injected with Friend lymphatic leukemia virus at birth developed a runt ing syndrome which was associated with a high incidence of hemolytic anemia. The anemia was characterized by the presence of incomplete anti‐erythrocyte autoantibodies detected by the direct antiglobulin test and the indirect enzyme‐augmented hemagglutination assay, and, in some cases, was followed by glomerulonephritis. This system in the rat may represent a new model of autoimmune hemolytic anemia in man.