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Cytostasis of lymphoma cells in suspension: Probable non‐thymic origin of the cytostatic lymphoid cells in mice bearing MSV‐induced tumors
Author(s) -
Senik A.,
De Giorgi L.,
Gomard E.,
Levy J. P.
Publication year - 1974
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910140314
Subject(s) - cytostasis , lymphoma , spleen , lymphatic system , immune system , cancer research , neoplasm , suspension culture , pathology , chemistry , immunology , biology , medicine , cell culture , cytotoxicity , in vitro , biochemistry , genetics
Lymphoid cell suspensions of MSV‐tumor‐bearing mice were studied in the cytostasis assay (CA) against syngeneic lymphoma cells in suspension. Pretreatment by anti‐θ serum and complement, carbonyl iron and a magnet, or filtration through antiimmunoglobulin‐coated glass bead columns shows that macrophages are probably the main effector cells of the cytostatic anti‐tumor effect demonstrated by the CA, which further illustrates the diversity of the anti‐tumor immune response in the MSV system.