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Mobility of concanavalina receptors on the surface membrane of lymphocytes from normal persons and patients with chronic lymphocytic leukemia
Author(s) -
BenBassat Hannah,
Goldblum Natan,
Manny Noga,
Sachs Leo
Publication year - 1974
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910140310
Subject(s) - chronic lymphocytic leukemia , concanavalin a , leukemia , receptor , immunology , lymphocyte , cell surface receptor , chronic leukemia , cell , medicine , biology , biochemistry , in vitro , acute leukemia
Lymphocytes, isolated from the peripheral blood of normal persons and patients with chronic lymphocytic leukemia, have been studied for cap formation and agglutinability by Concanavalin A (Con A). Twenty‐eight to 32% of the lymphocytes from 12 normal persons formed a cap and there was a similar frequency in separated B cells. The lymphocytes from 12 patients with chronic lymphocytic leukemia showed 6‐10% cells with a cap. Lymphocytes from the leukemic patients had a higher degree of Con‐A‐induced agglutinability than the lymphocytes from normal persons, and both types of cell bound a similar number of Con A molecules. The results indicate that there are differences in the mobility of Con A receptors on the surface membrane of lymphocytes from normal persons and patients with chronic lymphocytic leukemia.