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Influence of interferon on virus‐particle synthesis in oncornavirus‐carrier lines. II. Evidence for A direct effect on particle release
Author(s) -
Billiau A.,
Edy V. G.,
Sobis H.,
De Somer P.
Publication year - 1974
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910140306
Subject(s) - interferon , virus , extracellular , uridine , virology , cell culture , biology , interferon alfa , electron microscope , chemistry , alpha interferon , rna , biochemistry , physics , genetics , gene , optics
Interferon treatment of murine C‐type oncornavirus carrier lines results in a drastic inhibition of extracellular virus formation. When such cells are subcultured in the presence of interferon, synthesis of extracellular C‐type virus remains depressed until the interferon treatement is discontinued. Cell‐associated virus as seen in the electron microscope or as detected by uridine incorporation is not proportionally inhibited. Several possibilities to explain this discrepancy are tested. The most likely hypothesis is that interferon treatment primarily inhibits virus release.