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Inheritance of susceptibility to friend mouse leukemia virus. XII. Effects of the Fv‐1 locus
Author(s) -
Odaka Takeshi
Publication year - 1974
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910140214
Subject(s) - biology , locus (genetics) , leukemia , genotype , genetics , virus , inbred strain , virology , gene
The genetic control of susceptibility to the Friend leukemia virus (FLV) complex was studied under conditions which excluded the effect of the Fv locus. From hybrids between two mouse lines which have the same Fv genotype, but differ from each other in response to FLV infection, partially inbred lines were established by selecting for high or low ability to support multiplication of the N‐tropic FLV complex. The results indicated that the Fv‐1 locus controls multiplication of the FLV complex and of the lymphatic leukemia virus (a viral component of FLV complex) and also the development of late splenomegaly. Gene interaction between Fv and Fv‐1 in determining the susceptibility to FLV complex was discussed.