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Herpesvirus ateles: Transformation in vitro of marmoset splenic lymphocytes
Author(s) -
Falk Lawrence,
Wright John,
Wolfe Lauren,
Deinhardt Friedrich
Publication year - 1974
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910140213
Subject(s) - marmoset , in vitro , lymphoblast , cell culture , biology , virology , herpesviridae , haplorhini , antigen , transformation (genetics) , virus , immunology , viral disease , genetics , paleontology , gene
Four lymphoblastoid cell cultures were established by transformation of marmoset splenic lymphocytes in vitro with Herpesvirus ateles (HVA). The association of HVA with each cell line was demonstrated by the recovery of HVA from the lymphoblastoid cells or from the culture fluids and by the demonstration of HVA antigens in a small percentage of cells of each lymphoblastoid culture. Intranuclear inclusion bodies were observed in three cultures examined but herpesvirus virions were observed in only one of three cell lines. The four cell cultures had properties of T‐lymphocytes.