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Urine œstrogen profiles OF Asian and North American women
Author(s) -
MacMahon Brian,
Cole Philip,
Brown James B.,
Aoki Kunio,
Lin Tong Ming,
Morgan Robert W.,
Woo NgaiChen
Publication year - 1974
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910140204
Subject(s) - urine , luteal phase , menstrual cycle , follicular phase , demography , gynecology , medicine , physiology , hormone , sociology
Œstrone (El), œstradiol (E2) and œstriol (E3) were measured in the urine of Asian and North American women aged 15‐19, 20‐24 and 30‐39 years, during the follicular and luteal phases of the menstrual cycle. Each urine specimen was characterized by its œstriol proportion, E3/(E1+E2+E3). In each age group and cycle phase Asians had lower concentrations of œstrone and œstradiol and a higher oestriol proportion than North Americans. The differences were greatest in the youngest age group. Differences between the women from two North American cities or between women from three Asian areas were small. The data support the idea that the œstriol proportion, especially among young women, is a correlate of subsequent breast cancer risk.