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Lipid analysis of cell nuclei in young and old Ehrlich ascites tumors
Author(s) -
Balint Zsuzsa,
Holczinger L.
Publication year - 1974
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910140111
Subject(s) - ascites , lipid droplet , lipid metabolism , ehrlich ascites , chemistry , cholesterol , composition (language) , biochemistry , medicine , endocrinology , tumor cells , biology , cancer research , linguistics , philosophy
The total lipid content of whole cells and isolated nuclei of Ehrlich ascites tumors was found to increase in parallel with increasing age. Mainly triglycerides were accumulated both in the cells and in the nuclei, but the nuclear fraction showed also an increase in the total cholesterol content. No marked accumulation of lipid droplets could be observed in isolated nuclei, and thus it can be presumed that in the course of aging the increase in neutral lipid content is due to a profound alteration in the lipid composition of lipid‐containing nuclear structures.