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Serum inhibitors of cellular immunity in human neuroblastoma. IgG subclass of blocking activity
Author(s) -
Jose David G.,
Skvaril Frantisek
Publication year - 1974
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910130204
Subject(s) - neuroblastoma , blocking (statistics) , subclass , in vitro , immunity , immunology , cellular immunity , cytotoxic t cell , humoral immunity , blocking antibody , immune system , biology , chemistry , antibody , cell culture , biochemistry , genetics , statistics , mathematics
Abstract An autochthonous in vitro assay of cytotoxic cellular immunity against neuro‐blastoma cells was used to measure the specific blocking activity of serum from three children with untreated neuroblastoma. The blocking sera were fractionated into four IgG subclasses and blocking activity was found to be associated with IgG 1 and IgG 3 , with lesser activity in IgG 4 proteins.