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Carcinogenicity of nitrosamines and methanesulphonate esters given intraperitoneally, in RF mice
Author(s) -
Clapp N. K.
Publication year - 1973
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910120320
Subject(s) - carcinogen , lung , nitrosamine , medicine , pathology , leydig cell tumor , leydig cell , cancer research , chemistry , biochemistry , hormone , luteinizing hormone
Single injections of dimethylnitrosamine (DMN), diethylnitrosamine (DEN), methyl methanesulfonate (MMS), and ethyl methanesulphonate (EMS) were given intraperitoneally to male RF mice at various doses. DEN induced lung adenomas, liver hepatomas and forestomach tumors (squamous‐cell carcinomas and papillomas) at all doses, and Leydig‐cell tumors of the testis at the highest dose given. DMN, while increasing lung tumor incidence, failed to induce liver tumors when given intraperitoneally —in contrast to high incidences obtained by oral administration. The reason for this difference is not obvious at this time. MMS and EMS were not carcinogenic as used in this study. None of these alkylating agents was leukemogenic.