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Expression of fetal antigens and tumor‐specific antigens in SV40‐transformed cells. II. Tumor transplantation studies
Author(s) -
Ting ChouChik,
Rodrigues Dennis,
Herberman Ronald B.
Publication year - 1973
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910120223
Subject(s) - hyperimmunization , antigen , transplantation , fetus , immunology , biology , spleen , immunization , histocompatibility , virology , medicine , pregnancy , human leukocyte antigen , genetics
The effect of immunization with fetal antigens and tumor‐specific antigens on the transplantation of SVT2, a BALB/c mouse tumor induced by Simian virus 40 (SV40), has been studied. Hyperimmunization with 5,000 R X‐irradiated, syngeneic fetuses of 1–2 weeks' gestation or syngeneic spleen cells gave no protection to SVT2 cell challenge. In contrast, immunization with SV40 or SV40‐transformed cells gave a 100‐ to 1,000‐fold protection. These results gave additional evidence that fetal antigens are different from tumor‐specific transplantation antigen (TSTA).