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BCG immunotherapy of local subcutaneous growths and post‐surgical pulmonary metastases of a transplanted rat epithelioma of spontaneous origin
Author(s) -
Baldwin R. W.,
Pimm M. V.
Publication year - 1973
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910120213
Subject(s) - medicine , adjuvant , immunotherapy , concomitant , epithelioma , subcutaneous injection , pathology , surgery , carcinoma , cancer , oncology
The potential value of BCG immunotherapy in the treatment of pulmonary metastases had been evaluated using a weakly immunogenic transplanted rat epithelioma. Subcutaneous injection of tumour cells in admixture with viable BCG retarded tumour development at this site and reduced the development of pulmonary metastases. Partial control of metastatic disease following surgical removal of subcutaneous tumour was obtained by intravenous injection of BCG, the main response being an increase in survival and reduction in the number of pulmonary metastases. Treatment was not rendered more effective by concomitant immunostimulation with irradiated tumour cells in admixture with BCG. These studies illustrate the potential of BCG adjuvant therapy, but support the concept that localization of BCG at the tumour site is a necessary requirement for effective tumour suppression.