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Cell‐surface and virion‐envelope antigens shared by radiation leukemia virus (RadLV) and other murine C‐type viruses
Author(s) -
Ferrer Jorge F.
Publication year - 1973
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910120209
Subject(s) - antigen , virology , biology , antiserum , murine leukemia virus , virus , leukemia , antibody , viral envelope , transplantation , immunology , medicine , surgery
The present studies demonstrate that rats recognize a tumor‐specific transplantation antigen (s) shared by tumors induced by Radiation Leukemia Virus (RadLV), Gross Leukemia Virus (GLV), Moloney Leukemia Virus (MLV) or Moloney Sarcoma Virus (M‐MSV), which is different from the type‐specific transplantation antigen (s) detected by mice. Direct cytotoxic tests and absorption experiments with specific antisera confirm and extend previous studies indicating that rats also form antibodies to a cell‐surface cross‐reacting antigenic determinant present in tumors induced by these viruses. Results ofcytotoxic tests with a monospecific guinea‐pig antiserum for the intraspecies group‐specific (gs‐1) antigen of murine leukemia viruses, suggest that this antigen is present at the cell surface of tumors induced by RadLV, GLV, or MLV, and hence that it may be responsible for the cross‐reactions observed between these tumors in the present study. The data indicate that the rat typing system also recognizes a type‐specific MLV antigen (s) and support the idea that some MLV‐induced leukemias may be superinfected and antigenically converted by GLV. Virus neutralization studies show that rats form antibodies to virion‐envelope antigens shared by RadLV, GLV and MSV.