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Increase of lymphocyte‐mediated tumor‐cell destruction by certain patient sera
Author(s) -
Hellström Ingegerd,
Hellström Karl Erik,
Warner Glenn A.
Publication year - 1973
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910120205
Subject(s) - cytotoxic t cell , melanoma , sarcoma , medicine , in vivo , immunology , carcinoma , breast carcinoma , cancer research , cancer , lymphocyte , in vitro , pathology , breast cancer , biology , biochemistry , microbiology and biotechnology
Sera from one patient with an ovarian carcinoma, one with sarcoma, one with a breast carcinoma, and four patients with melanoma were found to “potentiate” (i.e. increase) the cytotoxic effect of blood lymphocytes reactive to the respective type of tumor target cells. This effect was specific. Furthermore, sera from the breast cancer and sarcoma patients and from one of the melanoma patients “armed” (i.e. made cytotoxic) lymphocytes from non‐reactive donors, not having (had) the respective tumor studied. The possible relevance, in vivo, of these findings, and the frequency with which they occur, need further clarification.