Pilot experiments with EB virus in owl monkeys ( aotus trivirgatus ). I. Reticuloproliferative disease in an inoculated animal

A pilot experiment is described in which EB virus‐containing cultured lymphoblasts were inoculated into a group of three adult owl monkeys. Virion‐free cells were inoculated into three other monkeys, and four further animals were kept as uninoculated controls. One of the animals receiving the virus died after 14 weeks with a striking reticulopro‐liferative disease very compatible with certain forms of malignant lymphoma. The findings are described and their significance considered in relation to a possible onocgenic capacity for EB virus.