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Comparative effects of hypophysectomy, ergocornine and ergocornine‐reserpine treatments on rat mammary carcinoma
Author(s) -
Welsch Clifford W.,
Iturri Gloria,
Meites J.
Publication year - 1973
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910120121
Subject(s) - hypophysectomy , reserpine , mammary carcinoma , medicine , endocrinology , endocrine system , carcinoma , hormone
Sprague‐Dawley rats bearing DMBA‐induced mammary tumors were hypo‐physectomized or injected with ergocornine or with ergocornine plus reserpine. Each treatment caused a prompt and prolonged regression of the tumors. Hypophysectomy was shown to be more effective in promoting tumor regression than treatment with ergocornine alone. However, reserpine administered in combination with ergocornine produced mammary tumor regression not significantly different from that obtained after hypophysectomy. These results are believed to provide a basis for further studies with drugs or drug combinations that can influence hypothalamic and/or pituitary activity to promote mammary tumor regression, and thus serve as a possible alternative to endocrine ablative procedures.