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Cell‐mediated immunity and blocking factors in patients with tumours of the central nervous system
Author(s) -
Kumar S.,
Taylor G.,
Steward J. K.,
Waghe M. A.,
MorrisJones P.
Publication year - 1973
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910120120
Subject(s) - immunity , cell mediated immunity , blocking (statistics) , central nervous system , cell , immunology , lymphocyte , medicine , cancer research , biology , immune system , genetics , statistics , mathematics
Lymphocytotoxicity studies were carried out in both the autochthonous and allogeneic situations in nine astrocytomas, seven medulloblastomas and two ependy‐momas. Tumour type‐specific lymphocytotoxicity was demonstrated. The degree of lymphocyte‐mediated tumour‐cell killing did not decrease with the duration of apparent clinical cure. Higher degrees of tumour‐cell killing were found in the autochthonous as compared with the allogeneic combinations. Blocking factor was demonstrated in only three patients.