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Inhibition of lymphocyte cytotoxicity for human colon carcinoma by treatment with solubilized tumour membrane fractions
Author(s) -
Baldwin R. W.,
Embleton M. J.,
Price M. R.
Publication year - 1973
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910120109
Subject(s) - cytotoxicity , in vitro , cytotoxic t cell , lymphocyte , antigen , in vivo , colon carcinoma , immunology , melanoma , carcinoma , papain , biology , cellular immunity , cancer research , chemistry , pathology , colorectal cancer , medicine , biochemistry , cancer , enzyme , genetics , microbiology and biotechnology
The in vitro cytotoxic action of patients' lymphocytes against colon carcinoma cells was evaluated following incubation of the lymphocytes with papain‐solubilized tumour‐membrane preparations. Soluble extracts of pooled colon carcinomas inhibited cytotoxicity by sensitized lymphocytes, but similar extracts of normal colon or melanoma had no inhibitory effect. The results suggest that soluble tumour antigen may play a role in abolishing lymphocyte reactivity, and this is interpreted as supporting the concept that cellular immunity against tumours in vivo may be inhibited by circulating antigen.