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A rapid destructive effect of the Schmidt‐Ruppin strain of rous sarcoma virus on transformed rat cell lines
Author(s) -
Reinisch Carol L.,
Bang Frederik B.
Publication year - 1973
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910110328
Subject(s) - rous sarcoma virus , cytopathic effect , virus , strain (injury) , virology , cell culture , in vitro , antiserum , biology , inoculation , antibody , immunology , biochemistry , anatomy , genetics
A cytopathic effect was induced by the Schmidt‐Ruppin strain of Rous sarcoma virus (RSV‐SR) in five of nine rat tumor cell lines tested in vitro. The cells showed irreversible cytopathic change as early as 24‐48 h after infection. Of the leukemogenic and tumorigenic viral agents tested, only RSV‐SR induced the rapid Rous cytopathic effect. Virus was recovered 8 days after inoculation of the tumor cell lines XC and M41. The effect was neutralized by specific anti‐RSV‐SR antiserum. Correlation between oncogenicity of the rat tumor lines in the syngeneic host and their susceptibility to RSV‐SR was incomplete.