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Depression of complement activity in three strains of mice after tumor transfer
Author(s) -
Drake Walter P.,
Legendre Stephen M.,
Mardiney Michael R.
Publication year - 1973
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910110323
Subject(s) - cytolysis , complement (music) , in vivo , immune system , immunology , complement system , medicine , biology , in vitro , cytotoxicity , phenotype , biochemistry , microbiology and biotechnology , complementation , gene
Both immune adherence and hemolytic complement activity were measured as a function of time after either intraperitoneal or subcutaneous injection of six transplantable tumors carried in three strains of mice. There was a lack of correlation between complement activity measured by these assays in accord with other studies on human cancer patients. The data indicate that host complement activity was depressed in all cases following tumor transfer and suggest that the serotherapy of murine tumors using passively administered anti‐tumor serum may be compromised by host complement insufficient to mediate tumor cytolysis in vivo .