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Transplacental and combined long‐term effect of DDT in five generations of a‐strain mice
Author(s) -
Shabad L. M.,
Kolesnichenko T. S.,
Nikonova T. V.
Publication year - 1973
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910110320
Subject(s) - carcinogen , transplacental , strain (injury) , lung , life span , biology , in vivo , zoology , toxicology , physiology , medicine , endocrinology , pregnancy , genetics , fetus , placenta , evolutionary biology
A‐strain mice were given technical DDT in sunflower‐seed oil at daily dose levels of 50 ppm during their entire life span for F 0 generation and of 10 ppm for F 0 ‐F 5 consecutive generations. Exposure to both levels of DDT resulted in a significant increase of lung adenomas in F 0 generations: 36.66% by 50 ppm and 19.05% by 10 ppm of DDT. In F 1 ‐F 5 generations exposed to 10 ppm of DDT lung tumours appeared in F 1 (15.38%), in F 2 (24.00%), in F 3 (46.34%), in F 4 (43.24%) and in F 5 (12.69%). In control A mice lung tumours were not detected at 6 months of age, but were observed at 12 months in 10.88% and altogether (between 6 and 12 months) in 7.28%. In F 2 , F 3 and F 4 treated generations the incidence of lung adenomas was significant as compared to the controls. No other tumours were observed in the treated animals. The data obtained in vivo are discussed and compared with previous observations made in vitro . DDT must be evaluated as a weak carcinogen.