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Correlation between various cell‐surface antigens induced by murine leukemia virus in the rat: Serological analysis
Author(s) -
Kuzumaki Noboru,
Takeichi Noritoshi,
Sendo Fujiro,
Kodama Takao,
Kobayashi Hiroshi
Publication year - 1973
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910110309
Subject(s) - antigen , antiserum , serology , virology , biology , cell , virus , rickettsia , murine leukemia virus , leukemia , microbiology and biotechnology , c57bl/6 , transplantation , neoplasm , immunology , antibody , medicine , genetics , surgery
Analysis based on the cytotoxicity test using antisera produced in rats indicated the presence of various cell‐surface antigens on the tumors in WKA/Mk rats induced or artificially infected by Friend, Rauscher or Gross viruses. Each line of the tumor was found to have a common antigen, namely group‐specific cell‐surface antigen. A Gross type‐specific and Friend and Rauscher type‐specific cell‐surface antigens were also detected, in keeping with the observations in the mouse system. In addition, the present experiments strongly suggested that a Friend strain‐specific antigen was detected only on the cell‐surface of the tumors in WKA/Mk rats induced or artificially infected by Friend virus. These results were in parallel with the data of previously reported transplantation studies.