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Inhibition of hepatoma‐immune lymph‐node cell cytotoxicity by tumour‐bearer serum, and solubilized hepatoma antigen
Author(s) -
Baldwin R. W.,
Price M. R.,
Robins R. A.
Publication year - 1973
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910110304
Subject(s) - cytotoxicity , antigen , immune system , lymph node , lymphocyte , biology , effector , immunology , antibody , immunity , cell , antibody dependent cell mediated cytotoxicity , microbiology and biotechnology , cancer research , chemistry , in vitro , biochemistry
Sera from rats bearing transplanted aminoazo‐dye‐induced hepatomas inhibited the cytotoxicity of lymph‐node cells from tumour‐immune rats for plated hepatoma cells, when the sera were incubated with the effector cells, rather than target cells. In contrast, sera from hepatoma‐immune rats, which have previously been shown to block lymphocyte cytotoxicity at the level of the target cell, failed to inhibit lymph‐node cell cytotoxicity when pre‐incubated with the effector cells. The possibility that antigenic determinants could be responsible for lymphocyte inhibition is supported by the demonstration that papain‐solubilized hepatoma‐specific antigen preparations inhibited lymph‐node cell cytotoxicity. The role of specific antibody, antigen and immune complexes in the interaction between cellular immunity and humoral factors during tumour growth is discussed.